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In simulation experiments we are often interested in finding out how different input variable settings impact the response of the system. Rather than run hundreds of experiments for every possible variable setting, experimental design techniques can be used as a "short-cut" to finding those input variables of greatest significance. Using experimental-design terminology, input variables are referred to as factors, and the output measures are referred to as responses. Once the response of interest has been identified and the factors that are suspected of having an influence on this response defined, we can use a factorial design method which prescribes how many runs to make and what level or value to be used for each factor. As in all simulation experiments, it is still desirable to run multiple replications for each factor level and use confidence intervals to assess the statistical significance of the results.
One's natural inclination when experimenting with multiple factors is to test the impact that each individual factor has on system response. This is a simple and straightforward approach, but it gives the experimenter no knowledge of how factors interact with each other. It should be obvious that experimenting with two or more factors together can affect system response differently than experimenting with only one factor at a time and keeping all other factors the same.
One type of experiment that looks at the combined effect of multiple factors on system response is referred to as a two-level, full-factorial design. In this type of experiment, we simply define a high and low level setting for each factor and, since it is a full-factorial experiment, we try every combination of factor settings. This means that if there are five factors and we are testing two different levels for each factor, we would test each of the 25 = 32 possible combinations of high and low factor levels. For factors that have no range of values from which a high and low can be chosen, the high and low levels are arbitrarily selected. For example, if one of the factors being investigated is an operating policy for doing work (e.g., first come, first served; or last come, last served), we arbitrarily select one of the alternative policies as the high level setting and a different one as the low level setting.
For experiments in which a large number of factors are being considered, a two-level full-factorial design would result in an extremely large number of combinations to test. In this type of situation, a fractional-factorial design is used to strategically select a subset of combinations to test in order to "screen out" factors with little or no impact on system performance. With the remaining reduced number of factors, more detailed experimentation such as a full-factorial experiment can be conducted in a more manageable fashion.
After fractional-factorial experiments and even two-level full-factorial experiments have been performed to identify the most significant factor level combinations, it is often desirable to conduct more detailed experiments, perhaps over the entire range of values, for those factors that have been identified as being the most significant. This provides more precise information for making decisions regarding the best factor values or variable settings for the system. For a more concise explanation of the use of factorial design in simulation experimentation see Law and Kelton (1991).